EXcuses should be excised. Do you really want to lose weight and improve your health once and for all? Then stop making excuses and just do it! Sure, that's easier said than done. But you need to stop finding reasons why you can't start moving a healthier lifestyle, and start listing all the reasons why you should. Don't put it off until tomorrow. Start today, by doing something positive -- just one small thing -- toward your health and weight loss.
Kefir is a yogurt-like substance, but it actually contains less sugar and more protein than conventional yogurt while remaining packed with gut-friendly probiotics that can help you lose weight by aiding digestion. In one study, kefir displayed weight loss properties similar to those of milk and other dairy-rich products. Other probiotic-rich foods include kombucha, bone broth, and fermented items such as sauerkraut and kimchi.
When I was in the sixth grade, I first realized that I was heavier than the other girls. I thought, "Oh, I'm going into junior high school—I should try to lose weight so boys will like me, like me." From then on, my mom and I tried pretty much any popular diet from the early 2000s you could think of. She was always encouraging me to lose weight whenever she did. I would usually lose between 30 and 40 pounds on those diets, but I always put it back on—and then some.
In an accompanying comment, Corby Martin and Kishore Gadde write that the study shows that "a slow and steady approach does not win the race, and the myth that rapid weight loss is associated with rapid weight regain is no more true than Aesop's fable." They cite a number of potential short-term advantages of very low calorie diets and note that these diets are now well formulated and provide adequate protein and essential micronutrients. They are "safe if used under expert supervision," the write.
To reach your get-lean goal, you must also follow a get-lean diet, filled with the best foods to burn fat. Why? Even if you work out hard for an hour every day, that still leaves 23 more hours for you to wreck all your hard work in the gym with just one slip-up: a measly handful of chips, a beer with the guys, or a burger at lunch. Diet is a huge, so to speak, part of the fat-loss equation. It's the backbone of your entire plan, the foundation of a hard body.

Speaking of flavonoids, the waist-whittling compounds also exist in higher concentrations in red fruits such as watermelon, Pink Lady apples, and plums, meaning they also have the power to induce weight loss. In fact, a 2016 study in the journal BMJ found that people who eat a diet rich in flavonoid-heavy food tend to gain less weight, which could be promising seeing as many people tend to put on pounds as they age. In addition, anthocyanin, a specific flavonoid compound that gives red fruits their color, has been shown to reduce fat-storage genes.


Who is this class for: The example learner for this course is interested in improving their diet and is open to adopting new behaviors around cooking, grocery shopping, eating, and exercise. The learner should be over the age of 18 and should be in good health without any chronic diseases (such as diabetes, heart disease, high blood pressure, cancer, or food allergies.) Prior knowledge of nutrition principles for a healthy diet would be useful to the learner but is not required. Learners are required to seek approval from their primary care physician before starting the course.

Calcium and vitamin C team up well to boost metabolism, and broccoli is just one of several healthy foods that contain both nutrients. What sets broccoli apart from the others, however, is that the green veggie also contains kind of fiber that’s been shown to increase the digestion, absorption and storage of food, also known as the thermic effect of food or TEF. A revved up metabolism combined with an increased TEF is a match made in weight loss heaven!
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That said, carrying extra weight around the middle is also tied to increased heart risks, making it arguably unhealthier to be an overweight man than a plus-size woman. Big bellies, it turns out, are a sort of a double-edged sword when it comes to weight loss: They're an extra health risk for men, but give guys the edge when it comes to dropping pounds.
This double-blind clinical trial study was conducted on 42 obese and overweight individuals (25 < BMI < 35). Participants were selected from those, who referred to a nutrition clinic (Ahvaz, Iran). Participants were screened based on the inclusion and exclusion criteria. Inclusion criteria were lack of physical activity, no smoking, no alcohol drinking, no usage of herbal supplements and vitamins, and lack of weight changes in the last 6 months. Exclusion criteria included pregnancy, breastfeeding, use of drugs that effect metabolism, lipid and glycemic profile, eating disorder, diabetes, cardiovascular disease, kidney problems, thyroid, digestive, respiratory diseases, and cancer. Participants consuming more than 300 mg of caffeine daily (described as caffeine users) were excluded from the study (20). The level of physical activity was assessed weekly by phone. The subjects, who had moderate or various physical activities, were excluded from the study. 

Did bikini season sneak up on you? Is your soon-to-be worn wedding dress still just a touch too tight? Did a last-minute invite for a beach getaway come your way? You're a lucky dog – and a panicked one too because you want to drop pounds, and fast. These 10 diets are likely to help you lose significant weight within a year, according to a panel of experts who reviewed 38 plans for the U.S. News Best Diets rankings. Just remember: Short-term weight loss is markedly different from long-term weight loss, which is more important for your health.
Keto. Flexitarian. Paleo. Whole 30. Vegan. There are as many diets in existence as there are dangerous weight loss myths. So which eating style should you choose when you’re on a get-fit-quick and have just 10 days? Turns out, numerous studies have found it essentially doesn’t matter which plan you follow for rapid weight loss, be it low-carb or low-fat, as long as you’re eating fewer calories than you’re burning. The key is that it’s sustainable: a strategy that you can keep up for the week and a half—and beyond.
Sleeping for more than five hours a night might seem like a luxury for some, but it can have a serious impact on your overall health. Not getting the recommended 7-8 hours of shut-eye a night puts you at risk for fatigue the next day, which means you’re more likely to crave and snack on high-calorie comfort food. Try to go to bed sooner so you can get a little more sleep, which will help you eat less. And to blast fat even faster, don’t miss these essential 55 Ways to Boost Your Metabolism.
The average American consumes approximately 15.5 pounds of pasta each year—and most of it is the refined white stuff. Unfortunately, this type of noodle is usually void of fiber and micronutrients. Spaghetti squash, on the other hand, boasts only about 40 calories per cup—more than 75 percent fewer calories than a cup of plain pasta—and is an excellent source of vitamin A and potassium. Make this simple swap to jumpstart your weight loss and you’ll be fitting into your skinny jeans in no time! For more swaps to save you calories, don’t miss these 25 Food Swaps That Cut 2,500 Calories a Week.
What's more trustworthy than a diet built by experts from the Mayo Clinic? Created by doctors, nutritionists, and all-star chefs, the plan has a few phases: In the first, you should lose 6 to 10 pounds in two weeks. After that, you can expect to lose 1 to 2 pounds a week until you reach your goal weight. You're also given plenty of resources and advice to help you keep the weight off.
Losing weight through exercising and eating a healthy diet may be effective. A balanced and low-calorie diet up your chances of getting a slimmer waist considerably. These foods either help boost metabolism or help ease the process of digestion; both of which are key to healthy weight loss. But to make your weight loss journey more effective, it is important to include natural stimulators that can speed up weight loss. One of the most efficient weight loss stimulators is green tea.
Spoon Guru nutritionist Isabel Butler (MSc, ANutr) recommends that “the best way to reduce weight and maintain the weight loss is by simply eating a balanced and healthy diet, without refusing yourself particular foods… If you do cut out foods, you need to make sure your diet is still balanced and you are getting the nutrients your body needs from other sources.”  
"When going out for fast food, I used to get the large-size value meal. Now, I satisfy a craving by ordering just one item: a small order of fries or a six-piece box of chicken nuggets. So far, I've shaved off 16 pounds in seven weeks, and I'm on track to being thinner than my high school self for my 10-year reunion later this year." —Miranda Jarrell, Birmingham, AL
Still, when it comes to losing weight, working a few cups of brewed green tea into your diet isn’t necessarily a bad idea. “Like coffee, green tea may give you a mild boost, and if you don’t add sugar, it has no calories,” notes Consumer Reports’ chief medical adviser, Marvin M. Lipman, M.D. “So drinking it in place of sugary drinks such as soda can help you cut calories.” 
According to the National Weight Control Registry, a database that tracks more than 10,000 individuals who have lost 30+ pounds and kept them off for at least one year, 75 percent of the most successful dieters weigh in at least once a week. Now that you’ve reached the end of your 10-day diet pilot, step on the scale and jot down your progress. Ready to continue your progress? Stoke your fat-burning furnace with a copy of The Super Metabolism Diet! With the help of this book, you can quickly and easily turn your metabolism into a fat-melting machine.
The idea is that the fasting induces mild stress to the cells in your body, helping them become better at coping with such stress and possibly helping your body grow stronger. The verdict is still out regarding the diet’s long-term effectiveness with weight loss, according to a review of preliminary animal research published in January 2017 in Behavioral Sciences. (17)
Another popular mainstream diet, Dr. Barry Sears's plan is considered to be one of the first in the recent wave of "anti-inflammatory" plans. It sets you up for success by calibrating your plate to be a third protein and two-thirds carbohydrates (not starchy ones like potatoes, think colorful vegetables instead) with a little bit of MUFAs, or monounsaturated fatty acids (the good-for-you kind ) in the mix. 

Good news for java lovers: The caffeine in coffee could speed up your metabolism and help your body burn slightly more calories (about 26 per cup). A study in Physiology & Behavior found that the average metabolic rate of people who drank caffeinated coffee was 16% higher than those who drank only decaf. Just be mindful of how much cream and sugar you add to your cup, which could offset any health benefits the beverage provides.
We’ve said it before and we’ll say it again: fat is your friend! To be more specific, healthy fats will be your weight loss friends. Consider adding extra virgin olive oil to your diet and you might see the scale start to tip in your favor. One Journal of Women’s Health study discovered that an EVOO-enriched diet helped participants lose more weight than those on a low-fat diet. Like peanuts and avocados, extra virgin olive oil’s belly-blasting abilities are thought to be a result of the monounsaturated fats it contains.
"Researchers around the world say what really works is not just cutting calories but satisfying your hunger with the right kinds of foods," says Health’s Frances Largeman-Roth, RD. In fact, women following a low-fat diet who were allowed to fill up on all the fruit and vegetables they wanted lost 23% more weight than women on a low-fat diet alone, a new study from the United Kingdom reports.
Red tea, also known as rooibos, is a great choice for when you’re struggling with midday stress. What makes rooibos particularly good for soothing your mind is the unique flavanoid called Aspalathin. Research shows this compound can reduce stress hormones that trigger hunger and fat storage and are linked to hypertension, metabolic syndrome, cardiovascular disease, insulin resistance and type 2 diabetes.
Why not empower rice, quinoa and even oatmeal with the belly-fat burning properties of green tea? Tie 4 green tea bags onto a wooden spoon. Fill a small pot with 2 cups water; add wooden spoon and tea bags. Bring water to a boil and remove tea bags. Add the grains to the boiling tea water and cook as directed. Try it with these delicious Quinoa Recipes for Weight Loss!
You know all those high-calorie, sugar-laden recipe videos that litter your Facebook newsfeed? Fast-paced hands arranging layers of cookie dough, peanut butter cups, and chocolate brownie batter that come together to make a mouthwatering, decadent dessert that’s also ridiculously fattening. “The internet and social media sites are basically making you fat,” Lisa Hayim, MS, RD, and founder of The WellNecessities, told us for our article on The 30 Worst Flat Belly Mistakes Women Make. “If it isn’t 25 ways to eat tater tots then it’s [another] national [something] day. The internet has made it basically impossible to stay away from cravings and indulgences. These are not excuses to eat unhealthy food.” Next time you see one of these videos, scroll quickly past. Or better yet, unfollow the page completely, and follow Eat This, Not That! on Facebook for healthier videos and more slimming tips. 

Thank you for this meal plan. It is exactly what I needed and having the shopping list was great. It made me see that I needed to cut portions, eat better, and skip or significantly moderate sweets and alcohol. I have made some minor substitutions like doubling broccoli because I don’t like Brussels sprouts, but for the most part sticking to the plan. I expected to feel hungry and don’t with the snacks.

“A study published in Nutrition Journal found that participants who ate foods high in monounsaturated fats for lunch (in this case, half an avocado) reported a 40 percent decreased desire to eat for hours afterward. Monounsaturated fats from sources like olive oil, nuts and avocados can reduce cholesterol, promote weight loss, even boost memory.” — David Zinczenko, author of the  Zero Belly Cookbook

Your favorite childhood snack is good for your grown-up self, too. Because peanut butter is a great source of protein and healthy fats, it can curb hunger and keep you feeling full long after you're finished eating. Having small snacks during the day that include a lean protein such as peanut butter with complex carbs (like an apple or banana) can also help keep your metabolism running smoothly.

Australian researchers randomized 204 obese adults to either a 12-week rapid weight loss diet (with Nestlé's Optifast) or a 36-week gradual diet. A weight loss of 15% was the goal of both diets. Participants who lost at least 12.5% of their weight then participated in the second phase of the study, in which they were placed on a 144-week maintenance diet.
Eating regular meals is essential. Experts agree that you should go no longer than 4 to 5 hours between meals. Otherwise, intense hunger can trigger a binge. Some experts believe dieters have better control if they eat several mini-meals throughout the day. Choose the meal pattern that works best in your lifestyle, but make sure to eat at least three meals per day. 

Many diet plans cut out entire food groups, which can create nutrient deficiencies as well as health problems. For instance, if the diet is very low in carbohydrates and you have type 1 diabetes or type 2 diabetes, it’s probably not a good fit. And if it’s too restrictive and you’re pregnant or breastfeeding, then it’s not a good idea, either. Keep in mind that pregnancy is not a time for weight loss. Speak with your doctor before making any changes to your diet if you are pregnant or breast-feeding.
Dr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. After graduating from St. Louis University School of Medicine, he completed his Internal Medicine residency and Rheumatology fellowship at the University of California, Irvine. He is board-certified in Internal Medicine and Rheumatology.
Because they don’t cater to one person’s weird eating habits. They provide a general guide for normal palates. If you don’t like the food, make up your own plan. Or write up a plan for other picky eaters like yourself! Sounds like with the limited amount of food you find acceptable to eat, surely you shouldn’t be overweight. And if you rely on junky snack foods in place of these perfectly healthy AND flavorful options, nobody can help you but yourself.
Green tea can help you lose weight. Several studies have suggested that the flavonoids and caffeine in green tea can help elevate metabolic rate, increase fat oxidation and even improve insulin activity. One study showed that those who consumed green tea and caffeine lost an average of 2.9 pounds during a 12-week period, while sticking to their regular diet. Another study suggested the increase in calorie output was equal to about 100 calories over a 24-hour period.
Case Western Reserve University is a leading national research university located in Cleveland, Ohio. Through its seven schools and college, Case Western Reserve offers top-10 programs in health law, organizational behavior and social work and top-25 programs in biomedical engineering, international law, medicine and nursing. More than 4,000 undergraduate and nearly 6,000 graduate and professional students are enrolled at CWRU, representing all 50 states and more than 90 countries.
Garber, C. E., Blissmer, B., Deschenes, M. R., Franklin, B. A., Lamonte, M. J., Lee, I.-M., … Swain, D. P. (2011, July). Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: Guidance for prescribing exercise. Medicine & Science in Sports & Exercise, 43(7), 1334–1359. Retrieved from http://journals.lww.com/acsm-msse/Fulltext/2011/07000/Quantity_and_Quality_of_Exercise_for_Developing.26.aspx
Fermented foods: These enhance the function of good bacteria while inhibiting the growth of bad bacteria. Sauerkraut, kimchi, kefir, yogurt, tempeh, and miso all contain good amounts of probiotics, which help to increase good bacteria. Researchers have studied kimchi widely, and study results suggest that it has anti-obesity effects. Similarly, studies have shown that kefir may help to promote weight loss in overweight women.
Identifying and resolving typical weight loss hurdles — like flagging enthusiasm — is something Noom excels at. The initial questions that set up your profile, match you with a coach, and place you with a group, all intend to diagnose your learning style and what flavor of support you need. What kicks you into high gear, tough love or words of affirmation? How do you like to show support? How do you feel about goal setting?
Abazarfard, Z., Salehi, M., & Keshavarzi, S. (2014, May). The effect of almonds on anthropometric measurements and lipid profile in overweight and obese females in a weight reduction program: A randomized controlled clinical trial. Journal of Research in Medical Sciences: The Official Journal of Isfahan University of Medical Sciences, 19(5), 457–464. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116579/
New Delhi: With so many diet plans and methods out there, adopting the right forms of eating habits to lose weight can be confusing. Well, forget the expensive meal plans that claim to promote rapid weight loss, here's one easy, simple trick that can help you get rid of that stubborn belly fat and shed those extra pounds in no time. Green tea has been consumed for centuries for its immense health benefits. A growing number of studies have shown that the flavonoids and caffeine in green tea can boost metabolism, enabling the body to break down and process fat much faster.
It might make your breath smell a bit, but each clove of garlic is packed not just with toxin-battling antioxidants, but also a naturally occurring chemical called allicin. When digested, allicin reacts with the blood to create a product capable of killing off many harmful bacteria and viruses that your body may be harbouring – including in the digestive tract. A healthy gut it essential for achieve a flatter tummy – try adding a few raw cloves to your food just before serving to get the most out of it.
Nighttime snacking, for most of us, is a habit that can undermine weight loss success. That's because the calories we eat after dinner tend to be empty ones, from chips, cookies, etc. Brushing your teeth after supper will help you make dinner the last meal of the day. If you need a little something at night, try to satisfy the urge with few calories -- have a stick of gum, one piece of hard candy, or a cup of hot tea).
New Delhi: With so many diet plans and methods out there, adopting the right forms of eating habits to lose weight can be confusing. Well, forget the expensive meal plans that claim to promote rapid weight loss, here's one easy, simple trick that can help you get rid of that stubborn belly fat and shed those extra pounds in no time. Green tea has been consumed for centuries for its immense health benefits. A growing number of studies have shown that the flavonoids and caffeine in green tea can boost metabolism, enabling the body to break down and process fat much faster.

Studies led by Dr. Barbara Rolls at Pennsylvania State University as well as those of Drs. James Barnard and Christian Roberts at UCLA, who are following people attending the Pritikin Longevity Center, are particularly enlightening. They have documented that one of the best ways of reducing calorie intake without triggering increased hunger is to reduce the calorie density of the foods consumed. Put simply, a bowl of pasta with veggies and marinara can fill us up just as well as a bowl of pasta with cheesy Alfredo, but for less than half the calorie cost.
Starchy veggies (like potatoes) and processed whole grains (like whole-wheat bread) are foods I’d normally recommend eating in moderation, since they provide plenty of nutrients, fiber, and healthy carbs. However, high-carb foods aren’t your best friend when you’re looking to drop water weight. Essentially, when your body stores excess carbs, it stores them with water. So replacing carb-heavy foods with non-starchy veggies that still provide filling fiber without as much water retention is the way to go. For a week before your event, you can swap out the starchy carbs for more non-starchy vegetables to lose some water weight. (These are 10 things experts wish you knew about water weight.)
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Blending green tea and avocado makes for an excellent combination of protein, essential fatty acids, and antioxidants. Just combine a tablespoon of green tea, half an avocado, one banana, and enough hot water for everything to blend well (about half a cup). Seep the green tea in the heated water for half an hour, and process everything together in the blender to create a subtly sweet breakfast smoothie. 

Catechins are also credited for green tea’s cancer-fighting potential. These antioxidants have the ability to block the action of molecules called free radicals, which can cause changes in healthy cells that sometimes lead to cancer. But there’s no solid proof yet that the catechins in green tea help to prevent cancer in humans, despite some promising studies in test tubes and animals.
Wow… Thank you so much for this diet plan. I am following the plan and made a few substitutions for the things I do not eat BUT I make sure to follow the amount suggested & its working wonderfully. I even tried it with vegetarian substitutions for a day & ate tofu instead of chicken. This is my second week and I I’m so proud of myself and the results.. Not to mention it feels like I’m eating clean and when I eat clean I consume water far better then when I don’t . I’m also exercising just, simply walking 3 to 4 miles a day 5 days a week. Im not looking for life changeing results…lol but this plan is working. Looking forward to the summerrrrrrrr….!!!!!
I think the fact that I made gradual changes was part of my success. I didn't dive in head-first and get overwhelmed with my new habits. And now that I've hit my goal weight and I'm super active, I do eat out with friends occasionally. It's not realistic to cut going to dinner with friends and family out of my life altogether. Today, I'm so proud to say that I've successfully maintained my weight for five years!
Thank you for this meal plan. It is exactly what I needed and having the shopping list was great. It made me see that I needed to cut portions, eat better, and skip or significantly moderate sweets and alcohol. I have made some minor substitutions like doubling broccoli because I don’t like Brussels sprouts, but for the most part sticking to the plan. I expected to feel hungry and don’t with the snacks.
Green tea has emerged as one of the most popular health drinks lately. It is not just healthy, but is said to help you lose weight; thanks to the presence of numerous antioxidants and nutrients that provide plenty of health benefits. In fact, many studies have shown that green tea can increase fat burning, which can help you cut the extra flab. The high concentration of vitamins and minerals, in addition to the low calorie content, enhance your metabolism and improve your body's ability to burn energy. Pair your cupful of green tea with exercises and a balanced diet to ensure healthy weight loss. We tell you reasons as to why you should drink more green tea to lose weight.

This study affirms, as many have before, that we can in fact cut calories and, at the same time, eat till we’re full and satisfied when we reduce the calorie density of the foods we eat. The research found that all three strategies to reduce calorie density led to a spontaneous reduction in ad libitum calorie intake, but the reductions in calorie intake were significantly greater with fat reduction.
Delicious, full of antioxidants, AND they help you to lose weight? Tomatoes are definitely among our favourite fat-fighting foods. Tomatoes have been found to reduce inflammation and water retention in the body, as well as reversing leptin resistance. Leptin is a type of protein which helps to regulate metabolic rate and appetite, so our bodies rely on it to shed those extra pounds.
Salmon boasts significant anti-inflammatory properties thanks to its rich omega-3 fatty acid content, meaning it’s an excellent source of protein for those looking to jumpstart their weight loss. In fact, one study that examined the effects of weight loss and seafood consumption showed wild salmon to be the most effective at reducing inflammation—better than lean white fish and a fish-free diet. According to a study published in The Journal of Nutritional Biochemistry, fishy fatty acids may also signal thyroid cells in the liver to burn more fat.

Since avocados are packed with nutrients and healthy fats that can stimulate weight loss, it’s no surprise that avocado oil acts in a similar fashion. When Penn State University researchers compared those who consumed avocado oil with those who consumed a flax-safflower oil blend, they found that those who used just three tablespoons of avocado oil daily lost nearly two percent of their belly fat in just one month.


The video promises a surprise at the end. I can buy the program for only $47….No, now I can get the $27 he charges his good friends and his family. It got as low as $7 but they will charge me $40 after a week. I decided to go back to reading the book. After learning all this neat stuff about fast weight loss is better the book is now telling me that the video they wanted me to watch is all wrong. Further reading is telling me that I must exercise and diet. I wish it would make up its mind.
Find a tea you enjoy. Although all non-herbal tea comes from the same plant, their characteristics change according to the amount of time the leaves are exposed to air. The lightest is white tea, often made from unopened plant buds. Green tea is produced from the green leaves, while oolong and black teas are made from leaves that have been exposed to air. While many studies focus on green tea, you can gain benefits from any variety. Find a variety you enjoy drinking, and keep in mind that there is a lot of flavor variation within each category.
When it comes to cravings, protein drinks and bars may also help cure your need for sugar, says Juge. He recommends mixing a flavored protein powder in a blender with as much ice as possible, so it'll taste more like a milkshake. Day Five's protein shake includes a cup of berries, which will also help with sugar cravings. Once or twice per week, Juge adds, you can have a low-sugar, high-protein bar. The newest varieties taste more like candy bars, with state-of-the-art sweetening techniques.

We're now into a section about attitude. Yes! The right attitude can help you lose weight, however all of the generalizations about "most obese people." I'm really getting sick of being lumped into this arbitrary generalization. Really, again, where is the research that shows that most obese people think this and do this. Is it really most? Sorry, but everyone I know knows how freaking hard it is and we're sick of people telling us what we think. Really, it's not the problem. We know it's hard, we know we're eating the wrong stuff, we know we don't exercise enough. Stop putting words in our mouths, your assumptions are just another reason we're not motivated to lose weight...again completely counter to what the book promises when it says this book will motivate you. Um, no shaming and putting words in my mouth doesn't really motivate.
Stavrou, S., Nicolaides, N. C., Papageorgiou, I., Papadopoulou, P., Terzioglou, E., Chrousos, G. P., … Charmandari, E. (2016, July 31). The effectiveness of a stress-management intervention program in the management of overweight and obesity in childhood and adolescence. Journal of Molecular Biochemistry, 5(2), 63–70. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996635/
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