Starving yourself is certainly not a good idea. But if you're otherwise healthy, a brief period of extreme calorie restriction isn't likely to hurt you. You should tell your doctor what you're doing, and be sure to include protein in your diet (70 to 100 grams per day). Take a multivitamin, and eat potassium-rich foods (tomatoes, oranges, and bananas).

However, drinking regular green tea might not be as beneficial for weight loss as taking green tea supplements. Most of the studies researching how green tea helps weight loss looked explicitly at green tea extract, which concentrates the benefits in a small serving size. While regular green tea will also help you maintain a healthy weight, the benefits will not be as impressive.


This weight loss workout plan consists of both cardiovascular exercise and resistance training. The name of the game is to blitz fat, which means to burn as many calories as you can. Cardiovascular exercise burns a lot of calories, as such this weight loss workout plan is centred around cardio. And to really blitz the fat, you’ll be doing two types of cardio, steady-steate cardio and interval training.
A fat-burning superfood, grapefruit contains a compound that can lower the fat-storage hormone insulin, which in turn can lead to weight loss. In fact, eating half a grapefruit before each meal could help you lose up to a pound a week—even if you don't change anything else about your diet. Because grapefruits are 90% water, which fills you up, they also act as a natural appetite suppressant.
Creamy, foamy drinks might taste delicious, but they can have enough calories to serve as an entire meal — and that’s not even taking into account the amount of sugar and preservatives they contain. Make your own healthier versions instead. From pumpkin spice lattes to spiced hot apple cider, there’s a nutritious alternative for most high-calorie beverages

A myriad of different teas have been shown to aid weight loss, and green tea is no exception. In fact, a study published in The Journal of Nutrition found that after just two weeks, those who sipped four to five cups of the green brew each day, in addition to working out for 25 minutes, lost more belly fat than those who didn’t imbibe. Scientists attribute green tea’s ability to shrink waists to the beverages catechins, a type of antioxidant that hinders the storage of belly fat and facilitates rapid weight loss.


Keep your muscles guessing by cross training and trying different workouts or tweaking your usual routine. You’ll work new muscles and beat boredom while trying something new. Also, studies show that you’re more likely to stick with your daily exercise routine if you switch up your workouts. Are you a CrossFit junkie? Stretch out at a yoga class. Is running more your style? Try adding some speed intervals throughout your usual route.
Ranging from just-juice to just-tea cleanses, these typically short-term plans can be dangerous. “Detoxes and cleanses are usually low in calories, protein, and fiber, all nutrients that our bodies need to function,” says Alissa Rumsey, RD, who is in private practice in New York City. “These plans leave you feeling hungry and cranky, causing a rebound food binge once you stop the detox.”

Consequently, researchers have widely discredited the hCG diet, which involves using hCG injections, pellets, sprays, or drops, and consuming  as few as 500 calories daily. The diet is problematic not only because there’s a lack of research on hCG supplements, but also because  the calorie requirement is dangerously low, potentially leading to nutrient deficiencies, fatigue, hormone imbalances, blood clots, and other issues. Thus, most experts agree the hCG Diet is not safe for anyone, the Mayo Clinic notes. (35)
“Stop focusing on calories and start focusing on the quality of the foods you eat. High-quality diet options are natural, whole, minimally processed foods, like vegetables, fruits, nuts or seeds that offer a lot more nutritional value in the form of vitamins, minerals, healthy fats and fiber. These foods help tame hunger naturally and nourish our cells at the deepest level so that we aren’t left with constant cravings. — Michelle Loy, MPH, MS, CSSD, Registered Dietitian Nutritionist and owner of Go Wellness in Orange County, California
Can someone remind Treason May, her cabinet, Oily rag and the civil servants that they are negotiating for the UK not the EU. Also that we voted to LEAVE not stay. The EU does not move so progress is when May surrenders more. She is playing a version of statues with the British public, creeping ever close to BINO hoping we will not notice her moves until it is too late. Time for the vote of no confidence. Get someone who knows what they are doing!
Unlike traditional green tea, matcha preparation involves covering the tea plants with shade cloths before they’re harvested. This triggers the growth of leaves with better flavor and texture, which are hand selected, steamed briefly to stop fermentation, then dried and aged in cold storage, which deepens the flavor. The dried leaves are then stone-ground into a fine powder.
Losing weight is often considered a matter of beauty and vanity, and as a result, there is a multi-billion dollar industry based on a multitude of products that promise miraculous methods to lose weight quickly and easily. However, losing weight — particularly for those who are obese — isn’t easy. For some people experiencing overweight or obesity, rapid weight loss is a serious medical need that cannot be accomplished alone or through traditional weight loss methods.
“Mangoes are a great way to satisfy a sweet tooth and to help to ward off other cravings,” says Rania Batayneh, MPH, a nutritionist and owner of Essential Nutrition for You. Mangoes are high in fiber, magnesium, antioxidants, and iron (making them a great snack for women who may have iron deficiency or anemia), says Batayneh. “And because mangoes aid in digestion, you want to focus on eating the fruit versus just drinking the juice.”
Remember, this is a marathon, not a sprint. Changing every part of your lifestyle at once is overwhelming and sets you up for failure. Decide on making just one healthy change a week to allow yourself time to adapt. Whether it’s cooking your own meals four nights a week, adding just 20 minutes of fitness to your routine a day or swapping out that sugary coffee for green tea, all these changes will add up.
“Anytime you’re stressed, you probably go for food,” Dr. Seltzer says. (Have we met?!) That’s because cortisol, the stress hormone, stokes your appetite for sugary, fatty foods. No wonder it’s associated with higher body weight, according to a 2007 Obesity study that quantified chronic stress exposure by looking at cortisol concentrations in more than 2,000 adults’ hair.
“Across the world, guidelines recommend gradual weight loss for the treatment of obesity, reflecting the widely held belief that fast weight loss is more quickly regained," said the first author of the paper, Katrina Purcell, of the University of Melbourne, in a press release. "However, our results show that achieving a weight loss target of 12.5% is more likely, and drop-out is lower, if losing weight is done quickly.”

At the heart of its flexible system: SmartPoints. SmartPoints derive primarily from number of calories; sugar and saturated fat drive the number up, protein brings it down. Getting a feel for the number of points that different foods typically “cost” in order to stay on your daily “budget” is a great way to cultivate healthy decision-making: A fried chicken wing is 7 points, while 3 oz. of chicken breast without the skin is 2 points. A sugar-laden Coca-Cola is 9 points, but so is a dinner-sized serving of Moroccan chicken rice and potatoes. Some foods are zero points: fruits and vegetables, skinless chicken and turkey breast, seafood, eggs, nonfat yogurt. Being encouraged to eat certain items in this way helps to restructure your mindset around food.

Starving yourself is certainly not a good idea. But if you're otherwise healthy, a brief period of extreme calorie restriction isn't likely to hurt you. You should tell your doctor what you're doing, and be sure to include protein in your diet (70 to 100 grams per day). Take a multivitamin, and eat potassium-rich foods (tomatoes, oranges, and bananas).


Green is truly the color of health. Matcha helps to safely cleanse and purge the body of harmful elements. Chlorophyll the element that gives green tea and other plants their signature verdant color is also a powerful detoxifier, helping to eliminate both chemicals and heavy metals from the body. And because matcha is carefully shade-grown, it is substantially richer in chlorophyll than other green teas, making it a superior daily detox.
Chapter 10 talks all about self love, and I agree it is extremely important to have. I lost a lot of respect though because it starts off saying how people who are overweight have a lack of self esteem and look down on themselves viewing themselves as inferior...um, you spent a portion of this book shaming obese people and making generalizations. You treated obese people differently and shamed them then wonder why they have low self esteem or don't feel like they fit in. This chapter meant a whole lot less to me coming from you after reading the rest of book. In this chapter while talking about self love, you spend the whole time blaming the person for their own low self esteem. Telling them that everyone has flaws (so you just told this person they are flawed, with the assumption you're talking about being overweight as a flaw because that's what the book is about and it's already obvious you look down on obese people based on your language throughout the book.)
If in doubt, start at a lower level. You can always skip ahead if you feel it is too easy or switch to a more difficult plan. The great thing is that all of the plans burn calories and all of the plans require commitment. As long as you give it your best at every workout (and watch your calorie intake!), you will make progress, will burn calories, will drop the pounds and will get stronger.
The customized support and abundant resources come at a price. This varies based on the intensity of your weight loss goals; we paid $60 per month. (We made an account before purchasing and received a 50% off offer by email to incentivize our membership. Tease them in the same way and see if you get the same deal.) If you want to get a look at all these perks before you purchase, you can try Noom free for 14 days.
Red wine can actually be good for your health, thanks to the antioxidant resveratrol, which studies have shown is good for your health and could help you lose weight. But any more than one glass, and you’re opening yourself up to extra sugar, empty calories, and a boozy buzz, which may inhibit your ability to make healthy food choices. If you’re out to happy hour, stop at one glass and opt for club soda (which is calorie free) or water with lemon instead.
This high-fat, adequate-protein, low-carb fad diet sends the body into a state of ketosis, in which the body uses stored fat for energy. Research published in Clinical Cardiology suggests the ketogenic, or “keto,” diet can be an effective weight-loss method, but to be successful, you must follow the plan consistently with no cheat days — otherwise, you’re just eating a high-fat diet that may be high in unhealthy fats for no reason. (1)
Notes: Chop the sweet potatoes and halve the Brussels sprouts, and place on a sheet pan. Drizzle with 2 teaspoons olive oil, season with salt and pepper, and toss to coat. Roast at 450°F (230°C) until tender, about 15 minutes. Season the steak with salt and pepper. In a frying pan over medium-high heat, warm 1 teaspoon olive oil. Cook the steak until done to your liking, about 3 minutes per side for medium-rare. (Consuming raw or undercooked meats may increase your risk of foodborne illness.)

Cheese isn’t traditionally thought of as something you consume to encourage weight management, but calcium-rich Parmesan, when eaten in moderation, can help stave off sugar cravings that can easily lead to weight gain. How does that work, you ask? The native Italian cheese contains the amino acid tyrosine (a building block of protein) which has been shown to encourage the brain to release dopamine without any unhealthy insulin spikes. What’s more? The combination of calcium and protein found in dairy products such as Parmesan has been found to increase thermogenesis—the body’s core temperature—and thus boost your metabolism.
A myriad of different teas have been shown to aid weight loss, and green tea is no exception. In fact, a study published in The Journal of Nutrition found that after just two weeks, those who sipped four to five cups of the green brew each day, in addition to working out for 25 minutes, lost more belly fat than those who didn’t imbibe. Scientists attribute green tea’s ability to shrink waists to the beverages catechins, a type of antioxidant that hinders the storage of belly fat and facilitates rapid weight loss.

Ranging from just-juice to just-tea cleanses, these typically short-term plans can be dangerous. “Detoxes and cleanses are usually low in calories, protein, and fiber, all nutrients that our bodies need to function,” says Alissa Rumsey, RD, who is in private practice in New York City. “These plans leave you feeling hungry and cranky, causing a rebound food binge once you stop the detox.”
Since avocados are packed with nutrients and healthy fats that can stimulate weight loss, it’s no surprise that avocado oil acts in a similar fashion. When Penn State University researchers compared those who consumed avocado oil with those who consumed a flax-safflower oil blend, they found that those who used just three tablespoons of avocado oil daily lost nearly two percent of their belly fat in just one month.
The efficacy of Nutrisystem boils down to portion control. A tiny tray of frozen tuna casserole doesn’t provide a lot of nutrients or satisfaction, but if that’s all you have for dinner, you’re keeping calorie count low. We entered in a couple Nutrisystem meals and found their point count to be mid-high, between 7 and 9. Ultimately, tiny amounts of not-wholesome foods doesn’t teach you to eat well.
Because you’re consuming whole leaves in matcha, you may get three times as much caffeine than a cup of steeped tea, about the amount in a cup of brewed coffee. Matcha aficionados say that compared to the caffeine buzz from coffee, matcha creates an “alert calm” due to a natural substance it contains called l-theanine, which induces relaxation without drowsiness. Still, we do believe it’s best to nix all forms of caffeine (including matcha) at least six hours before bedtime, to ensure a good night’s sleep.
“The American Heart Association recommends that men eat less than 36 grams of added sugar and that women consume less than 24 grams. However, for optimal weight loss, I tell my male clients to consume less than 20 grams of sugar per day and I tell the women to consume less than 15 grams.The easiest way to cut back on the sweet stuff is by consuming less sugary drinks and dressings. Cut the sugar, lose the fat, regain your health and life.” — Dr. Sean M. Wells, DPT, PT, OCS, ATC/L, CSCS
If you’re constantly sleeping less than seven or eight hours a night, your health — and waistline — will suffer. In fact, in a 2013 study, researchers found that sleep-deprived subjects were much more likely to choose larger portions of snacks than those who slept at least eight hours at night. The lack of sleep also affected their food choices. (8)

Recent studies have also shown that garlic supports blood-sugar metabolism, and helps control lipid levels in the blood. What’s more? Eating garlic can help boost your immune system, help ward off heart disease, fight inflammation, increase memory retention, and lower blood pressure, so consider adding some to your next meal. At the very least, it is preferable over salt, which can lead to water weight gain and bloating.
”But science actually tells us the opposite,” says the professor. “Regardless of whether you pick a sensible diet, exercise, behavioural therapy or a drug, our analysis of the literature shows that it’s those who experience the greatest weight loss in the first 2-4 weeks who have the greatest weight loss the following year. So if you’ve lost a lot of weight after one month, you’re more likely to have lost a lot of weight after a year or two.”
Starchy veggies (like potatoes) and processed whole grains (like whole-wheat bread) are foods I’d normally recommend eating in moderation, since they provide plenty of nutrients, fiber, and healthy carbs. However, high-carb foods aren’t your best friend when you’re looking to drop water weight. Essentially, when your body stores excess carbs, it stores them with water. So replacing carb-heavy foods with non-starchy veggies that still provide filling fiber without as much water retention is the way to go. For a week before your event, you can swap out the starchy carbs for more non-starchy vegetables to lose some water weight. (These are 10 things experts wish you knew about water weight.)

Scrolling through your social media one last time may be most people’s pre-bed ritual, but it can seriously mess with your sleep cycle. The light from your screen can suppress melatonin, the hormone that controls sleep. And getting plenty of shut-eye is important for your waistline; a study published in the journal Sleep found that people who didn’t get the recommended 7-8 hours of sleep a night were more at risk for weight gain. Try to put your phone away 20 minutes before your bedtime to avoid the light distraction.
Do you mindlessly sprinkle salt on your food without even tasting it first? Stop it! Seriously. Extra sodium can lead to water weight gain and bloating, which will make your pants fit tighter (and the number on the scale tick up). Be sure to read your labels, too; sodium is typically lurking in in processed foods, even “healthy” ones like frozen dinners and canned soups.
Many diets, including Atkins and the keto diet, fit into this umbrella. A typical low-carb diet limits carbs to less than 60 g daily, but this can vary, according to the Mayo Clinic. (15) In a September 2015 review published in PLOS One, people following low-carb diets saw modest weight loss — although study authors note that long-term effects of the diet require further research. (16)

“A study by David Jenkins, MD, PhD—the University of Toronto pioneer in low-glycemic eating — demonstrates that eating small portions at frequent intervals is good for your health in a number of remarkable ways. Within the study, they found that people who ate every three hours reduced their blood cholesterol by over 15% and their blood insulin by almost 28%. That’s key, because in addition to regulating your blood sugar level, insulin plays a pivotal role in fat metabolism, inflammation and the progression to metabolic syndrome. When your body produces less insulin, you’re much less likely to convert dietary calories into body fat.
“Before you begin to change your diet, spend a week recording everything you eat—and I mean everything. Before I made any changes to my diet, I journaled everything I ate each day for a week, including little things like gum or breath mints. If you have a piece of candy from your coworker’s desk, snag a few spoonfuls of your boyfriend’s ice cream, or finish the few bits of grilled cheese your kid left on her plate, write it down! It all adds up, and you just don’t realize how much you’re eating until you actually see it all on paper in front of you. I, for one, was stunned.” — Maria Menounos, author of  The Everygirl’s Guide to Diet and Fitness, on how she lost 40 pounds
Weight Watchers, which not only champions a sustainable diet but has sustained itself for over fifty years, is a favorite amongst nutritionists. Its practical, flexible philosophy of saving and splurging SmartPoints boils down to balancing out food choices. You can get tips, tools, and motivation by attending the traditional weekly meetings, or get the same resources through its user-friendly app. Either way, research proves that Weight Watchers’ social element supports weight loss. At about $4 a week, OnlinePlus costs about half as much as Meetings+OnlinePlus, which runs around $8 (your fees vary depending on the length of your commitment).
There are countless ways to enjoy the fruit (yes, technically it is one), but you can't beat the classic combination of whole-wheat toast with mashed avocado, lemon juice, and sunflower seeds. Sass also recommends whipping avocado into a smoothie, pureeing it with herbs and citrus juice to make a creamy salad dressing, or adding it to a veggie omelet.

So I'm 5'4 and weigh 167 pounds. I have gained a lot in the last one year. My goal is to loose up to 30 lbs. I have a trainer 3 days a week. I am vegetarian where I do not eat ANY meat or seafood. How to loose weight faster. I am toning cause of my workout. I intake 2 ProteinZ sysnthesis shakes a day. But my weight is not going down. I was size 6 before. Now I'm size 10. I am 39 years old with hypo thyroid issues. It's hard to keep weight off. Any suggestions.


Spirulina is a high-protein seaweed supplement that’s typically dried and sold in powdered form. The dried stuff is about 60 percent protein, and, like quinoa, it’s a complete protein, meaning it can be converted directly into muscle in the body and is thus a great weight loss tool. A tablespoon of the blue-green algae delivers 8 grams of metabolism-boosting protein for just 43 calories, plus half a day’s allotment of vitamin B12, which in and of itself can give you more energy and boost your metabolism. Try tossing some spirulina into a smoothie and watching the pounds melt off. For more skinny smoothie ideas, check out this list of 56 Smoothies for Weight Loss!
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Also known as yam or yambean, this Mexican turnip is a great source of fiber, says Dr. Jaime Schehr, a registered dietitian in New York City. “This plant is great for weight loss due to its high fiber to sugar ratio (a whopping 32g of fiber per medium jimaca—that’s almost an entire day’s worth). They are also a good source of potassium, an essential mineral in maintaining water balance in our body.”
“A cup of blackberries has only 62 calories and is packed with fiber and phytochemicals, including powerful flavonoids and anthocyanins, which help to speed stool and toxins through your digestive system,” says Maleeff. Their high water and fiber content, plus sweet taste, make them the perfect refreshing summer weight-loss food. (These blackberry yogurt cheesecake parfaits are perfect for dessert!)
Samantha reportedly first tried a few quick-fix diet pills to help her lose weight that summer, but after getting unsatisfactory results, she decided to overhaul her diet and drastically cut out all the cookies and fast food she had been eating last August. But Samantha says she still wasn't shedding a lot of weight until she replaced her five cups of sugary tea for unsweetened green tea.
If you’re trying to shed excess weight, use all three calorie-density-reduction strategies. While this study showed that cutting the amount of fat added to foods was the single most effective way to reduce ad libitum calorie intake, it is clear that all three methods were effective. Furthermore, they are not mutually exclusive, so it is likely that using all three in combination would work even better than each one used alone.
What happens if you fast for a day? What happens if you don't eat for a day? While most people will feel hungry and possibly tired, there is also a range of other effects. In this article, learn about how the body starts to burn fat for energy and whether fasting for 24 hours can be a good weight loss tool. We also investigate the possible risks. Read now
What an absolute load of rot...never having to the publics knowledge been pregnant ,even she cannot possibly know if she can conceive ,Harry himself as far as we know has sired nothing. Being so much older for a first child ,its often more difficult ,you cannot make predictions like this. All you can say is the expert has a 50% chance of being right.
Spirulina is a high-protein seaweed supplement that’s typically dried and sold in powdered form. The dried stuff is about 60 percent protein, and, like quinoa, it’s a complete protein, meaning it can be converted directly into muscle in the body and is thus a great weight loss tool. A tablespoon of the blue-green algae delivers 8 grams of metabolism-boosting protein for just 43 calories, plus half a day’s allotment of vitamin B12, which in and of itself can give you more energy and boost your metabolism. Try tossing some spirulina into a smoothie and watching the pounds melt off. For more skinny smoothie ideas, check out this list of 56 Smoothies for Weight Loss! 

The fad military diet consists of low-calorie, odd food pairings such as bun-less hot dogs with banana, carrots, and broccoli. “Any diet like the military diet that severely limits the amount of calories you consume or eliminates one or more entire food groups puts any individual at risk for nutrient deficiencies,” says Kyle. “This can be more harmful than holding onto those 10 extra lbs you’re trying to lose.” (32)
A new player in the weight loss program space, Noom packs a lot of behavioral psychology into one sophisticated app. It aims to help you identify and break bad habits, and have some fun doing it. The powerful app echoes Weight Watchers’ successful community approach, but outleagues that program in terms of learning resources. While it’s the more expensive of our two favorite programs, it’s the richer when it comes to virtual experience — with personalized lessons, tasks, and support that made us look forward to opening up the app.
“I tell all of my celebrity and professional-athlete clients to get between 6 and 8 hours of sleep per night. Everyone is overly focused on food, water and exercise, all of which are extremely imperative to weight loss and optimal health. However, without proper sleep, all of these the other factors are null and void. When you don’t get enough sleep, levels of the hormone leptin drop, which increases appetite. This surge in appetite makes comfort food more appealing, which can derail weight loss efforts.” — Jay Cardiello, celebrity fitness and nutrition expert 

Blending green tea and avocado makes for an excellent combination of protein, essential fatty acids, and antioxidants. Just combine a tablespoon of green tea, half an avocado, one banana, and enough hot water for everything to blend well (about half a cup). Seep the green tea in the heated water for half an hour, and process everything together in the blender to create a subtly sweet breakfast smoothie. 
In the first phase of the study, 50% of people on the gradual diet and 81% of people on the rapid diet achieved the 12.5% weight loss goal. Both groups struggled considerably in the second phase: 71.2% in the gradual diet group and 70.5% in the rapid diet regained most of the weight they had shed in the first phase. In both groups, patients who successfully completed phase 1 lost a little over 14 kilograms in the first phase but then gained back all but 4 kg in the second phase.
One easy trick if you're a pasta fan is to swap out white pasta for the wonderfully named courgetti (spaghetti made from spiralizing courgette). You’ll hardly notice the difference when you’re eating it, but you’ll be fuller for longer despite consuming fewer calories. When you consume fewer calories, your body can go to your fat reserves for energy, rather than just burning off the food you’ve eaten.  
“Use a VersaClimber or take a VersaClimber class. These machines are still not that common, but in my opinion they are far more effective for weight loss than other forms of cardio. They require you to use a large portion of your muscles and it’s functionally better for you than other forms of cardio like spinning. Everyone is talking about Rise Nation in LA at the moment as they are the first dedicated VersaClimbing studio. There’s no harder cardio workout I have tried. To lose fat you have to put in the work. — Dan Roberts, celebrity trainer and creator of Methodology X
Second, take a few photos of yourself to keep your motivation up. "Most of the people who come to me are doing it for a reason," he explains. "They're going on vacation, competing in a bodybuilding show, or maybe going to a reunion. I always have them strive for that goal. I take front, side, and back pictures of them at the beginning and have them post the photos on their mirror at home. I tell them, just keep looking at that picture and think of what you're going to look like in a few weeks."
“Use a VersaClimber or take a VersaClimber class. These machines are still not that common, but in my opinion they are far more effective for weight loss than other forms of cardio. They require you to use a large portion of your muscles and it’s functionally better for you than other forms of cardio like spinning. Everyone is talking about Rise Nation in LA at the moment as they are the first dedicated VersaClimbing studio. There’s no harder cardio workout I have tried. To lose fat you have to put in the work. — Dan Roberts, celebrity trainer and creator of Methodology X
A myriad of different teas have been shown to aid weight loss, and green tea is no exception. In fact, a study published in The Journal of Nutrition found that after just two weeks, those who sipped four to five cups of the green brew each day, in addition to working out for 25 minutes, lost more belly fat than those who didn’t imbibe. Scientists attribute green tea’s ability to shrink waists to the beverages catechins, a type of antioxidant that hinders the storage of belly fat and facilitates rapid weight loss.
A myriad of different teas have been shown to aid weight loss, and green tea is no exception. In fact, a study published in The Journal of Nutrition found that after just two weeks, those who sipped four to five cups of the green brew each day, in addition to working out for 25 minutes, lost more belly fat than those who didn’t imbibe. Scientists attribute green tea’s ability to shrink waists to the beverages catechins, a type of antioxidant that hinders the storage of belly fat and facilitates rapid weight loss.
dChanges between groups, for normally distributed variables, paired-sample t test and independent-sample t test were used to investigate differences within and between groups, respectively. For non-normally distributed variables, the Wilcoxon signed rank and Mann-Whitney U tests were used to assess differences within and between groups, respectively.
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